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1996-03-09
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Document 0058
DOCN M9650058
TI [Effect of primary prevention of Pneumocystis carinii pneumonia on the
inaugural clinical and biological presentation of AIDS: 624 cases
(Aquitaine Cohort, 1985-1994)]
DT 9605
AU Morlat P; Hubert JB; Chene G; Buisson M; Paty MC; Lasseur C; Constans J;
Bernard N; Beylot J; Service de medecine interne, hopital Saint-Andre,
Bordeaux,; France.
SO Rev Med Interne. 1995;16(11):815-7. Unique Identifier : AIDSLINE
MED/96145680
AB In a cohort of HIV-infected patients, this study compares the clinical
and immunological features at the time of AIDS diagnosis of patients who
either received primary Pneumocystis carinii prophylaxis (P+; n = 335)
or who did not (P-; n = 289). Frequency of P carinii pneumonia was lower
in P+ than in P- patients (14.9% vs 26.0%; p < 0.001). Conversely,
toxoplasmic encephalitis, esophageal candidiasis, cytomegalovirus
disease and M avium complex disease were more frequent in P+ patients.
CD4+ count (median/mm3) at the time of AIDS diagnosis was lower in P+
than in P- patients: 22 vs 97 (p < 0.001); this suggests that early
intervention delays the onset of AIDS for about one year. While
searching for new prevention strategies against other opportunistic
infections, efforts should be expanded to improve prophylaxis of P
carinii pneumonia which remains in France the most frequent first
AIDS-related illness.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY AIDS-Related
Opportunistic Infections/EPIDEMIOLOGY/*PREVENTION & CONTROL Cohort
Studies English Abstract Female France/EPIDEMIOLOGY Hospitals,
University Human HIV Infections/DRUG
THERAPY/*EPIDEMIOLOGY/PHYSIOPATHOLOGY HIV-1 Male Pneumonia,
Pneumocystis carinii/EPIDEMIOLOGY/*PREVENTION & CONTROL Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).